Hofman, J., Sorf, A., Vagiannis, D., Sucha, S., Novotna, E., Kammerer, S., Küpper, J.-H., Ceckova, M., Staud, F. Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance. Drug Metab. Disp., DOI:  10.1124/dmd.119.086975

Steinbrecht, S., Kammerer, S., Küpper, J.-H.HepG2 cells with recombinant cytochrome P450 enzyme overexpression: Their use and limitation as in vitro liver model. J. Cell. Biotechnol., DOI:  10.3233/JCB-189013

Krüger-Genge, A., Blocki, A., Franke, R.-P., Jung, F.Vascular Endothelial Cell Biology: An Update. Int. J. Mol. Sci. DOI:  10.3390/ijms20184411

Haileka, V., George, S., Steinbrecht, S., Jung, F., Reinehr, R., Küpper, J.-H. Colon cancer cells cultured under hyperosmotic conditions as in vitro model to investigate dehydration effects on cancer drug susceptibility.  Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-199210

Schulz, C., Kammerer, S., Küpper, J.-H.NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies. Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-199226

Gerk, U., Franke, R.-P., Jung, E.-M., Scheller, B., Krüger-Genge, A., Jung, F. Imaging of coronary arteries using ionic versus non-ionic radiographic contrast media: Intraindividual comparison study. Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-199217

Hofman, J., Sorf, A., Vagiannis, D., Sucha, S., Kammerer, S., Küpper, J.-H., Chen, S., Guo, L., Ceckova, M., Staud, F. Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes. Mol. Pharmaceut. DOI:  10.1021/acs.molpharmaceut.9b00361

Lau, S., Rangarajan, R., Philidet, C., Krüger-Genge, A., Braune, S., Kammerer, S., Küpper, J.-H., Lendlein, A., Jung, F. Effects of acrolein in comparison to its prodrug cyclophosphamide on human primary endothelial cells in vitro.Toxicol. In Vitro., DOI: 10.1016/j.tiv.2019.104685.

Steinbrecht, S., König, R., Schmidtke, K.-U., Herzog, N., Scheibner, K., Krüger-Genge, A., Jung, F., Kammerer, S., Küpper, J.-H.Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4. Toxicology, DOI: 10.1016/j.tox.2018.11.008

Kammerer, S., Küpper, J.-H. Optimized protocol for induction of cytochrome P450 enzymes 1A2 and 3A4 in human primary-like hepatocyte cell strain HepaFH3 to study in vitro toxicology. Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-189321

Kammerer, S., Küpper, J.-H.Expert Opinion: Human Hepatocyte Systems for in vitro Toxicology Analysis. Journal of Cellular Biotechnology., DOI: 10.3233/JCB-179012

Krüger-Genge, A., Steinbrecht, S., Küpper, J.-H., Lendlein, A., Jung, F. Evidence for cytostatic effect of cyclophosphamide on human vein endothelial cells in cancer therapy: preliminary in vitro results. Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-189125

Nowak, E., Kammerer, S., and Küpper, J-H. ATP-based cell viability assay is superior to trypan blue exclusion and XTT assay in measuring cytotoxicity of anticancer drugs Taxol and Imatinib, and proteasome inhibitor MG-132 on human hepatoma cell line HepG2. Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-189120

Krüger-Genge, A., Braune, S., Walter, M, Schiemann, M,  Kratz, K.,  Küpper, J.-H., Lendlein, A., and Jung, F.Influence of surface treatments of poly(n-butyl acrylate) networks on fibroblasts adhesion, morphology and viability.Clin.Hemorheol.Microcirc., DOI: 10.3233/CH-189130

Nowak, E., Martin, F., George,S., Röber, N., Conrad, K., and J.-H. Küpper. Bacterial production and purification of immunoreactive paraneoplastic neurological syndrome autoantigen Ma2. Journal of Cellular Biotechnology  2 85–91, 2016/2017

Kade, S., Herzog, N., Schmidtke, K.-U., Küpper, J.-H.Chronic ethanol treatment depletes glutathione regeneration capacity in hepatoma cell line HepG2.Journal of Cellular Biotechnology 1: 183-190, 2016

Herzog, N.; Hansen, M., Miethbauer, S., Schmidtke, K., Anderer, U., Lupp, A., Sperling, S., Seehofer, D., Damm, G., Scheibner, K., Küpper, J.-H.Primary like human hepatocytes genetically engineered to obtain proliferation competence display liver biotransformation activity in 2D and 3D culture systems. Cell Biol Int.Mar;40(3):341-53, 2016

George, S., Rödiger, S., Schröder, C., Knaut, M., Küpper, J.-H. Development of multiplex PCR systems for expression profiling of human cardiomyocytes induced to proliferate by lentivirus transduction of upcyte genes.Journal of Cellular Biotechnology, 2: 35-55, 2016

Meyer, R., Meyer-Ficca, M., Küpper, J.-H.Adenoviral vectors for modulation of poly(ADP-ribose) polymerase-1 (PARP1) – dependent DNA repair as a predictive tool for chemotherapy. Journal of Cellular Biotechnology 2: 57-68, 2016

Herzog, N., Katzenberger, N, Martin, F., Schmidtke, K.-U., Küpper, J.-H.Generation of cytochrome P450 3A4-overexpressing HepG2 cell clones for standardization of hepatocellular testosterone 6β-hydroxylation activity. Journal of Cellular Biotechnology 1: 15-26, 2015

George, S., Noack, M., Vanek, M, Rentzsch, J. Röber, N., Roggenbuck, D., Conrad, K., Küpper, J.-H.Expression of nicotinic acetylcholine receptor subunits in HEp-2 cells for immunodetection of autoantibody specificities in sera from Myasthenia gravis patients. Clin.Hemorheol.Microcirc. 61: 385-396, 2015

George, S., Paulick, S., Knütter, I., Röber, N., Hiemann, R., Roggenbuck, D., Conrad, K., Küpper, J.-H. Stable Expression of Human Muscle-Specific Kinase in HEp-2 M4 Cells for Automatic Immunofluorescence Diagnostics of Myasthenia Gravis. PLOS one, 9: e83924, 2014

George, S., Georgi, M., Roggenbuck, D., Conrad, K., Küpper, J.-H.A strategy for cell-based multiplex diagnostics of Myasthenia gravis and autoimmune encephalitis by modifying the subcellular localization of cell membrane autoantigensgravis. Clin.Hemorheol.Microcirc., 58, 211-228, 2014

Rudat, V., Bachmann, N., Küpper., J.-H., Weber, K.-J. Trans-dominant inhibition of poly(ADP-ribosyl)ation suppresses rejoining of ionizing radiation-induced DNA double-strand breaks. Intern. J. Radiat. Biol., 77, 303-307, 2001.

Meyer, R.G., Küpper, J.-H., Kandolf, R., and Rodemann, H.-P. Negative regulation of the human egr-1 promoter by the p38MAP/SAPK2 pathway in cancer cell cultures. Europ. J. Biochem. 269: 337-346, 2002.

Weber, K., Brück, P., Mikes, Z., Küpper, J.-H., Klingenspor, M., and Wiesner, R.J. Glucocorticoid hormone stimulates mitochondrial biogenesis specifically in skeletal muscle. Endocrinology 143:177-184. 2002

Selinka, H.-C., Wolde, A., Pasch, A., Klingel, K., Schnorr, J.J., Küpper, J.-H., Lindberg, A.M. and Kandolf, R. Comparative analysis of two coxsackievirus B3 strains: Influence of virus-receptor interactions on pathogenesis. J. Med. Virol. 67: 224-33, 2002. 

Grassi, G., Maccaroni, P., Meyer, R., Kuhn, A., Kaiser, H., D'Ambrosio, E., Pascale, E., Grassi, M., Kandolf, R., Di Nardo, P., and Küpper, J.-H. Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression and modulate cell cycle progression in human gliobastoma cell line U87., Carcinogenesis, 24: 1625-1635, 2003.

Mathlouthi, R., Aberle, S., Schug, N., Küpper, J.-H., Schröder, K., Seitz, G., Blin, N. Assessing Optimal Promoter Activity for Constructs in Gastrointestinal Gene Therapy. Anticancer Res., Sep-Oct;23(5A):4011-5, 2003.

Aberle, S., Schug, N., Mathlouthi, R., Seitz, G., Küpper, J.-H., Schröder, K., Blin, N. Promoter selection for the cytosine deaminase suicide gene constructs in gastric cancer. Europ. J. Gastroent. Hepat 16: 63-67, 2004.

Meyer, R. G., Meyer-Ficca, M. L., Kaiser, H., Kandolf, R., and Küpper, J.-H. Efficient plasmid-based generation of recombinant coxsackievirus B3 particles for transfer of capsid gene replacement replicons in viral infection models. Virus Res. 104: 17-26, 2004.

Meyer-Ficca, M. L., Meyer, R. G., Kaiser, H., Brack, A. R., Kandolf, R., and Küpper, J.-H. Comparative Analysis of inducible Expression Systems in transient Transfection Studies. Anal. Biochchem. 334: 9-19, 2004.

Neuhof, D., Zwicker, F., Kuepper, J.-H., Debus, J., Weber, K.J. Activation of telomerase by ionizing radiation: differential response to the inhibition of DNA double-strand break repair by abrogation of poly(ADP-ribosylation) by LY294002 or by Wortmannin.Int.J.Radiat.Oncol.Biol.Phys. 69: 887-894, 2007

Paulick, S., Noack, M., George, S., Herzog, N., Conrad, K., Roggenbuck, D., Küpper, J.-H. Generierung von rekombinanten Zellinien zur Multiparameterdiagnostik von Autoimmunerkrankungen: Diagnostik der Myasthenia gravis mit Autoantigen-exprimierenden HEp-2 Zellen. In: Conrad K, Roggenbuck D., Lehmann W, Schedler U, Peine G (Hrsg.) Multiparameteranalytik in Forschung und Praxis. Immundiagnostische Bibliothek, Band 7, Pabst Science Publishers, Berlin, Seiten 53-66, 2011

Küpper, J.-H., van Gool, L., and Bürkle, A. Molecular genetic systems to study the role of poly(ADP-ribosyl)ation in the cellular response to DNA damage. Biochimie 17, 450-455, 1995.

Küpper, J.-H., van Gool, L., Müller, M., and Bürkle, A. Detection of poly(ADP-ribose) polymerase and its reaction product poly(ADP-ribose) with immunocytochemistry. Histochem. J. 28, 391-395, 1996.

Küpper, J.-H., Müller, M, and Bürkle, A. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen-induced gene amplification in SV40-transformed Chinese hamster cells. Cancer Res. 56, 2715-2717, 1996.

Küpper, J.-H., and Müller, M. Improved protocols for the isolation and in-situ cryopreservation of cell colonies. Cytotechnology 21, 225-229, 1996.

van Gool, L., Meyer, R., Tobiasch, E., Cziepluch, C., Jauniaux, J.-C., Mincheva, A., Lichter, P., Poirier, G. G., Bürkle, A., and Küpper, J.-H. Overexpression of human poly(ADP-ribose) polymerase in transfected hamster cells leads to increased poly(ADP-ribosyl)ation and cellular toxicity of g-irradiation. Europ. J. Biochem. 244, 15-20, 1997.

Bernges, F., Bürkle, A., Küpper, J.-H., and Zeller, W. J. Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells. Carcinogenesis (London) 18, 663-668, 1997. 

Küpper, J.-H., Wolf, I., and Bürkle, A. NAD+ loading of mammalian cells by electrotransfection leads to increased poly(ADP-ribosyl)ation capacity. Biochimie 79, 175-178, 1997.

Rudat, V., Küpper, J.-H., Weber, K. J., and Wannenmacher, M. Trans-dominant inhibition of poly(ADP-ribosyl)ation leads to decreased sublethal and potentionally lethal damage recovery. Intern. J. Radiat. Biol. 73, 325-330, 1998.

Affar E. B., Duriez, P. J., Shah, R. G., Bourassa, S., Küpper, J.-H., Bürkle, A., and Poirier, G. G. Dot-immunoblot method for detection of poly(ADP-ribose) synthesized in vitro and in vivo. Anal. Biochem. 259, 280-283, 1998.

Küpper, J.-H. Sensibilisierung von Tumorzellen für Chemo- und Strahlentherapie - Die Rolle des Schutzfaktors PARP. In: Krebsforschung heute. Seiten 151-152. Steinkopff Darmstadt, 1998.

Tatsumi-Miyajima, J., Küpper, J.-H., Takebe, H., and Bürkle, A. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle vector mutagenesis in Chinese hamster cells. Mol. Cell. Biochem, 193: 31-35, 1999.

Hans, M.-A., Müller, M., Meyer-Ficca, M., Bürkle, A., and Küpper, J.-H. Overexpression of dominant negative PARP interferes with tumor formation of HeLa cells in nude mice: Evidence for increased tumor cell apoptosis in vivo. Oncogene 18, 7010-7015, 1999.

Pasch, A., Küpper, J.-H., Kandolf, R., Selinka, H.-C. Comparative analysis of virus/host cell interactions of a hemagglutinating and a non-hemagglutinating strain of coxsackievirus B3. J. Gen. Virol. 80, 3153-3158, 1999.

Küpper, J.-H., Müller, M., Wolf, I. NAD+ consumption in carcinogen-treated hamster cells overexpressing a dominant negative mutant of poly(ADP-ribose) polymerase. Biol. Biophys. Res. Commun. 265, 525-529, 1999.

Geisen, C., Denk, C., Küpper, J.-H., and Schwarz, E. Growth inhibition of cervical cancer cells by the human retinoic acid receptor beta gene. Int. J. Cancer 85, 289-295, 2000.

Beneke, R., Geisen, C., Zevnik, B., Bauch, T., Müller, W.-U., Küpper, J.-H., Möröy, T. DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53. Mol. Cell. Biol., 20 (18), 6695-703, 2000.

Meyer R., Müller M., Beneke S., Küpper J.-H., Bürkle A. Poly(ADP-ribose) polymerase: a negative regulator of alkylation-induced sister-chromatid exchanges. Int J Cancer, 88:351-5, 2000.

Küpper, J.-H., de Murcia, G., and Bürkle, A. Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells. J. Biol. Chem. 265, 18721-18724, 1990.

Grube, K., Küpper, J.-H., and Bürkle, A. Direct stimulation of poly(ADP ribose) polymerase in permeabilized cells by double-stranded DNA oligomers. Anal. Biochem. 193, 236-239, 1991.

Bürkle, A., Grube, K., and Küpper, J.-H. Poly(ADP-ribosyl)ation: its role in inducible DNA amplification, and its correlation with the longevity of mammalian species. Exp. Clin. Immunogenet. 9, 230-240, 1992.

Bürkle, A., Grube, K., and Küpper, J.-H. Poly(ADP-ribosyl)ation, genetic instability, and aging. In: R. Zwilling and C. Balduini (eds.), Biology of Aging, Reihe der Villa Vigoni Band 1, pp. 137-145. Berlin, Heidelberg, New York: Springer Verlag, 1992.

Küpper, J.-H., and Bürkle, A. Expression of the DNA-binding domain of human poly(ADP-ribose) polymerase as a trans-dominant inhibitor of poly(ADP-ribosyl)ation in transfected eucaryotic cell lines. In: G.G. Poirier and P. Moreau (eds.), ADP-Ribosylation Reactions, pp. 38-46. New York: Springer Verlag, 1992.

Bürkle, A., Grube, K., and Küpper, J.-H. Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity. In:G.G. Poirier and P. Moreau (eds.), ADP-ribosylation reactions, pp. 178-184. New York: Springer Verlag, 1992

Bürkle, A., Chen, G., Küpper, J.-H., Grube, K., and Zeller, W.J. Increased poly(ADP-ribosyl)ation in intact cells by cisplatin treatment. Carcinogenesis (London) 14, 559-561, 1993.

Molinete, M., Vermeulen, W., Bürkle, A., Ménissier-de Murcia, J., Küpper, J.-H., Hoeijmakers, J.H.J., and de Murcia, G. The poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in living cells. EMBO J. 12, 2109-2117, 1993.

Bürkle, A., Müller, M., Wolf, I., and Küpper, J.-H. Poly(ADP-ribose) polymerase activity in intact or permeabilized mononuclear blood cells of mammalian species differing in longevity. Mol. Cell. Biochem. 138, 85-90, 1994.

Küpper, J.-H., Müller, M., Jacobson, M.K., Tatsumi-Miyajima, J., Coyle, D.L., Jacobson, E.L., and Bürkle, A. Trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyoma virus replicon. Mol. Cell. Biol. 15, 3154-3163, 1995.

Bürkle, A., Grube, K., Müller, M., Wolf, I., Heller, B., and Küpper, J.-H. Poly(ADP-ribose) polymerase: correlation of enzyme activity with life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation. In: Cutler, R.G., Packer, L, Bertram, J., and Mori, A. (eds.), Oxidative Stress and Aging:. 111-121. Basel, Birkhäuser Verlag, 1995.

Küpper, J.-H., Müller, M., Jacobson, M.K., Tatsumi-Miyajima, J., Coyle, D.L., Jacobson, E.L., and Bürkle, A. Trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against g-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyoma virus replicon. Mol. Cell. Biol. 15, 3154-3163, 1995.

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