12800 - Microbial Metabolism Modulübersicht
Module Number: | 12800 |
Module Title: | Microbial Metabolism |
Stoffwechsel der Mikroorganismen | |
Department: | Faculty 2 - Environment and Natural Sciences |
Responsible Staff Member: |
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Language of Teaching / Examination: | English |
Duration: | 1 semester |
Frequency of Offer: | Every winter semester |
Credits: | 5 |
Learning Outcome: | Goal of the lecture is
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Contents: | Microbial Metabolism and Regulation As a general principle all statements presented in the lectures are based on conclusions drawn from original data. Topics: a) Mutations affecting metabolic pathways: (conditional) auxotrophy; supplementation; glycine biosynthesis; definded growth media; b) Isoenzymes: isocitrate DHs; serine hydroxymethyltransferases; carbon flux analysis; subcellular compartmentation; aspartate kinases of E. coli c) Regulation of metabolism: lac, ara, trp operon; repression, induction, attenuation, mRNA half-life control;; adenylation of glutamine synthetase; phosphorylation; feed back inhibition d) Circadian clocks: control of photosynthesis and nitrogenase in Synechococcus and Anabaena; sporulation in Neurospora e) Reporter systems: lacZ; green fluorescent protein; organelle targeting; f) Quorum sensing: biofilms; signal systems in Gram-positive and Gram-negative bacteria; |
Recommended Prerequisites: | Basic knowledge in biochemistry, molecular biology, microbiology. |
Mandatory Prerequisites: | none |
Forms of Teaching and Proportion: |
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Teaching Materials and Literature: | About 30 pdf-files of original research reports, review articles, PhD theses are available for the students e.g. Biochem J 369: 263-73; PNAS 100: 5914-9; Genes Develop 15:1468-80; YEAST 21: 63-73; EMBO J 22: 2127-34; J Bacteriol 185: 2066-79; Schlüpen C Diss Uni Düsseldorf; PNAS 90: 5672-6; PNAS 99: 9697-702; Microbiology 154: 2184-94; Mol Cell Biol 6221-8; BBA 1577: 240-50; J Mol Cat 10: 335-43; PNAS 98: 12221-6; J Bacteriol 182: 1-8; J Biol Chem 271: 11113-9; Microbiol 147: 3377-86; PNAS 107: 2043-47 |
Module Examination: | Final Module Examination (MAP) |
Assessment Mode for Module Examination: | Written Examination (120 min) |
Evaluation of Module Examination: | Performance Verification – graded |
Limited Number of Participants: | None |
Part of the Study Programme: |
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Remarks: | "Recommended Placement in the Study Plan" Biotechnology (Master of Science, 3 Semester Version): Master 1st year course Biotechnology (Master of Science, 4 Semester Version): Master 2nd year course |
Module Components: |
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Components to be offered in the Current Semester: |