Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity. Radushev V, Karkossa I, Berg J, von Bergen M, Engelmann B, Rolle-Kampczyk U, Blüher M, Wagner U, Schubert K, Rossol M (shared senior autorship). Frontiers in Immunology. 2024 Jul 10:15:1416543 DOI: 10.3389/fimmu.2024.1416543

Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes. Raulien N, Friedrich K, Strobel S, Raps S, Hecker F, Pierer M, Schilling E, Lainka E, Kallinich T, Baumann S, Fritz-Wallace K, Rolle-Kampczyk U, von Bergen M, Aigner A, Ewe A, Schett G, Cross M, Rossol M, Wagner U (shared senior authorship). Science Signaling. 2024 Jul 16;17(845):eadd8913 DOI: 10.1126/scisignal.add8913

Triclosan and its alternatives, especially chlorhexidine, modulate macrophage immune response with distinct modes of action. Raps S, Bahr L, Karkossa I, Rossol M, von Bergen M, Schubert K. Sci Total Environ. 2024 Mar 1:914:169650. DOI: 10.1016/j.scitotenv.2023.169650

Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages. Murthy S, Karkossa I, Schmidt C, Hoffmann A, Hagemann T, Rothe K, Seifert O, Anderegg U, von Bergen M, Schubert K, Rossol M.Cell Death Dis. 2022 Jan 12;13(1):53. DOI: 10.1038/s41419-022-04507-3

Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals. Thrum S, Sommer M, Raulien N, Gericke M, Massier L, Kovacs P, Krasselt M, Landgraf K, Körner A, Dietrich A, Blüher M, Rossol M, Wagner U. Int J Obes (Lond) 2022 Oct;46(10):1883-1891. DOI: 10.1038/s41366-022-01135-x

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Jäger E, Murthy S, Hahn M, Strobel S, Schmidt C, Peters A, Stäubert C, Sungur P, Venus T, Geisler M, Radusheva V, Raps S, Rothe K, Scholz R, Jung S, Pierer M, Seifert O, Chang W, Estrela-Lopis I, Raulien N, Krohn K, Sträter N, Hoeppener S, Schöneberg T, Rossol M, Ulf Wagner U (shared authorship). Nature Communications. 2020 Aug 25;11(1):4243. DOI: 10.1038/s41467-020-17749-6 

Perturbation of the Monocyte Compartment in Human Obesity. Friedrich K, Sommer M, Strobel S, Thrum S, Blüher M, Wagner U, Rossol M. Front Immunol. 2019 Aug 8;10:1874 DOI: 10.3389/fimmu.2019.01874

Fatty Acid Oxidation Compensates for Lipopolysaccharide-Induced Warburg Effect in Glucose-Deprived Monocytes. Raulien N, Friedrich K, Strobel S, Rubner S, Baumann S, von Bergen M, Körner A, Krueger M, Rossol M, Wagner U (shared authorship). Front Immunol. 2017 May 29;8:609. DOI: 10.3389/fimmu.2017.00609

GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses. Quandt D, Rothe K, Baerwald C, Rossol M. Sci Rep. 2015 Nov 25;5:16719. DOI: 10.1038/srep16719

Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.Rossol M, Pierer M, Raulien N, Quandt D, Meusch U, Rothe K, Schubert K, Schöneberg T, Schaefer M, Krügel U, Bräuner-Osborne H, Baerwald C, Wagner U. Nature Communications. 2012;3:1329. DOI: 10.1038/ncomms2339

Pubmed link to all publications of M. Rossol:  Pubmed