Focus of our working group

  • Generation and culture of proliferation competent cells (upcyte®/EPCC technology) using primary human cells from biopsy material (hepatocytes, tumor cells, mesenchymal cells)
  • Overexpression of phase I and phase II enzymes in different cell lines to study therapeutic effects of drugs and drug metabolites
  • Isolation of microsomes from CYP450 overexpressing cell clones for metabolite analysis
  • Development of new biotechnological methods for the cell-free synthesis of liver enzymes (phase I and phase II) within a Fraunhofer project group
  • Toxicological and functional studies of xenobiotics and their phase I and phase II metabolites in hepatocytes, tumor cells, mesenchymal cells and blood cells
  • Age-dependent and age-associated effects of drugs and drug metabolites
  • Providing autoantigens for immunodiagnostics of myasthenia gravis and autoimmune hepatitis
  • Analysis of the influence of cyanobacterial products (e.g. aqueous extracts from Arthrospira platensis) on human cells


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