11825 - Tissue Engineering Modulübersicht

Module Number: 11825
Module Title:Tissue Engineering
  Entwicklung und Kultivierung von Geweben
Department: Faculty 2 - Environment and Natural Sciences
Responsible Staff Member:
  • Prof. Dr. rer. nat. Schubert, Kristin
Language of Teaching / Examination:English
Duration:1 semester
Frequency of Offer: Every summer semester
Credits: 5
Learning Outcome:

• Explain and apply fundamental scientific principles as well as advanced, specialized knowledge in tissue engineering and regenerative medicine.

• Describe the basic structure of tissues and analyze interactions between cells and the extracellular matrix.

• Explain key developmental processes in mammals and relate them to tissue engineering strategies.

• Identify and explain the core components of tissue engineering, including cells, signaling molecules, biomaterials, bioreactors, and three-dimensional (3D) cell culture systems.

• Distinguish between different cell-based therapies and evaluate their roles as therapeutic concepts in regenerative medicine.

• Analyze and discuss 3D cell culture approaches and evaluate their relevance for tissue engineering, disease modeling, toxicology and pharmacology and translational research.

• Develop independent ideas and concepts for solving scientific problems related to tissue engineering.

Contents:

• Basic organisation of tissues: Cells and extracellular matrix (ECM)

• ECM: Molecular structure & function • Cell-ECM Interaction

• Cell-Cell interactions • Cellular Development and Fate Decisions (Proliferation, migration, determination, differentiation, cell-cell & cell-matrix interaction, apoptosis)

• Cells Sources for Tissue Engineering: stem cells, differentiated cells from adult tissues, problem of donor-recipient cell transfer

• Wound healing as a Natural Model of "Tissue Engineering": Inflammation, tissue formation, tissue remodelling

• Cell based therapies: Principles and Applications

• 3D Cell Cultures Systems: Principles and Applications

Recommended Prerequisites:Basic knowledge in cell biology
Mandatory Prerequisites:none
Forms of Teaching and Proportion:
  • Lecture / 2 Hours per Week per Semester
  • Seminar / 1 Hours per Week per Semester
  • Self organised studies / 105 Hours
Teaching Materials and Literature:
  • Molecular Biology of The Cell, Alberts et al., 5th/6th edition, Garland Sciences, 2008/2015
  • Cell and Molecular Biology. Concepts and experiments. Karp G., John Wiley & Sons, 2008
  • Principles of Tissue Engineering, Lanza R. P. et al., Academic Press, 2nd edition 2000
  • Methods of Tissue Engineering, Anthony Atala, Robert P. Lanza (eds.), Academic Press, New York, 2002
  • Tissue Engineering, Clemens van Blitterswijk (senior editor), Elsevier, Amsterdan,Boston, Heidelberg, … (2008)
  • Functional Tissue Engineering, Farshid Guilak, David L. Butler, Steven A. Goldstein, David Mooney, C. MacLachlan, Springer, New York, Berlin, 2003
  • Specific original scientific publications
Module Examination:Final Module Examination (MAP)
Assessment Mode for Module Examination:Written Examination (120 min)
Evaluation of Module Examination:Performance Verification – graded
Limited Number of Participants:None
Part of the Study Programme:
  • Abschluss im Ausland / Biotechnologie / keine PO
  • Master (applied) / Biotechnology / PO 2018
  • Master (applied) - Extended Semester / Biotechnology / PO 2018
  • Abschluss im Ausland / Environmental and Resource Management / keine PO
  • Abschluss im Ausland / Medizininformatik / keine PO
Remarks:
Module Components:
  • Lecture "Tissue Engineering"
  • Seminar "Tissue Engineering"
  • Examination "Tissue Engineering"
Components to be offered in the Current Semester: