11825 - Tissue Engineering Modulübersicht

Module Number: 11825
Module Title:Tissue Engineering
  Entwicklung und Kultivierung von Geweben
Department: Faculty 2 - Environment and Natural Sciences
Responsible Staff Member:
  • Prof. Dr. rer. nat. Anderer, Ursula
Language of Teaching / Examination:English
Duration:1 semester
Frequency of Offer: Every summer semester
Credits: 5
Learning Outcome:
  • After successful participation in the module, the students can explain and apply scientific basics as well as specialized and deepened knowledge. They can develop independent ideas and concepts for solving scientific and professional problems.They are able to
  • discuss basic structure and interactions of cells and extracellular matrix in tissues.
  • discover embryonic developmental processes in mammals as a basis for tissue engineering processes.
  • know the definition, history, scientific and therapeutical background of "Tissue Engineering".
  • know the basic elements of tissue engineering (cells, molecules, biomaterials, bioreactors).
  • discrimate between different cell based therapies as therapeutic concept in Regenerative Medicine.
  • Students acquire expertise in basic elements and methods of Tissue Engineering and will be able to discuss tissue engineering approaches with respect to the application in the lab and in the clinic.
Contents:
  • Definition and history of tissue engineering
  • Basic organisation of tissues: Cells and extracellular matrix (ECM)
  • ECM: Molecular structure & function
  • Cell-ECM-Interaction: Function & relevance, interacting possibilities
  • Development of tissues and multicellular organisms: Morphogenesis (Proliferation, migration, determination, differentiation, cell-cell & cell-matrix interaction, apoptosis) 
  • Wound healing, a natural process of "tissue engineering": Inflammation, tissue formation, tissue remodelling
  • Cells, biomaterials, specific molecules and bioreactors used in tissue engineering approaches
  • Cells for Tissue Engineering: stem cells, differentiated cells from adult tissues, problem of donor-recipient cell transfer
  • Cell based therapies: Basic principles and applications
  • Biomaterials: natural and synthetic biomaterials, surface modifications, (dis-)advantages
  • Bioreactors and special culture conditions
  • Mechanical conditioning of cells and mechanochemical transduction
Recommended Prerequisites:Basic knowledge in cell biology
Mandatory Prerequisites:none
Forms of Teaching and Proportion:
  • Lecture / 2 Hours per Week per Semester
  • Seminar / 1 Hours per Week per Semester
  • Self organised studies / 105 Hours
Teaching Materials and Literature:
  • Molecular Biology of The Cell, Alberts et al., 5th/6th edition, Garland Sciences, 2008/2015
  • Cell and Molecular Biology. Concepts and experiments. Karp G., John Wiley & Sons, 2008
  • Principles of Tissue Engineering, Lanza R. P. et al., Academic Press, 2nd edition 2000
  • Methods of Tissue Engineering, Anthony Atala, Robert P. Lanza (eds.), Academic Press, New York, 2002
  • Tissue Engineering, Clemens van Blitterswijk (senior editor), Elsevier, Amsterdan,Boston, Heidelberg, … (2008)
  • Functional Tissue Engineering, Farshid Guilak, David L. Butler, Steven A. Goldstein, David Mooney, C. MacLachlan, Springer, New York, Berlin, 2003
  • Specific original scientific publications
Module Examination:Final Module Examination (MAP)
Assessment Mode for Module Examination:Written Examination (120 min)
Evaluation of Module Examination:Performance Verification – graded
Limited Number of Participants:None
Part of the Study Programme:
  • Abschluss im Ausland / Biotechnologie / keine PO
  • Master (applied) / Biotechnology / PO 2018
  • Master (applied) - Extended Semester / Biotechnology / PO 2018
  • Abschluss im Ausland / Environmental and Resource Management / keine PO
  • Abschluss im Ausland / Medizininformatik / keine PO
Remarks:
Module Components:
  • Lecture "Tissue Engineering"
  • Seminar "Tissue Engineering"
  • Examination "Tissue Engineering"
Components to be offered in the Current Semester: