Das Vorlesungs- und Seminar-Material ist ab Montag, den 06.04.2020 auf der Moodle-Lernplattform verfügbar!
The lecture slides and the documents for the seminar will be available at the Moodle learning platform on Monday the 6th of April! The material for the laboratory course "Methods in Synthetic Microbiology" will be provided at the beginning of the event!
Soil bacteria are endowed with broad metabolic capacities and flexible regulatory networks. Both features enable the bacteria to adjust their catabolic and anabolic pathways to compete with their fellows and other microbes for the nutrients, which are available in a given ecological niche. We are mainly working with the Gram-positive soil bacteria Bacillus subtilis and Listeria monocytogenes that are ubiquitous in the environment. B. subtilis is a harmless bacterium serving as a model system in basic research and as a workhorse for various industrial applications. In B. subtilis, we study how essential building blocks like amino acids are synthesized. We also investigate how the bacterium adapts to perturpation of the metabolic network at the genome level and how underground metabolism contributes to the evolution of novel metabolic pathways. In the Minibacillus project, we aim to construct a minimal cell based on B. subtilis. Our goal is to identify the minimal gene set that is needed to sustain life. Like B. subtilis, L. monocytogenes thrives in diverse environmental niches. Moreover, L. monocytogenes has the remarkable ability to invade and reproduce inside human cells when ingested with contaminated food. The bacterium possesses sophisticated regulatory systems for the adaptation to these extremely different environments. In L. monocytogenes, we study the role of an essential signaling nucleotide in osmoadaptation. Finally, we are interested in the evolution of herbicide tolerance of soil bacteria.
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