14117 - Enzymes in Drug Development Modulübersicht

Module Number: 14117
Module Title:Enzymes in Drug Development
  Enzyme in der Arzneimittelentwicklung
Department: Faculty 2 - Environment and Natural Sciences
Responsible Staff Member:
  • Prof. Dr. rer. nat. Scheibner, Katrin
Language of Teaching / Examination:English
Duration:1 semester
Frequency of Offer: Every winter semester
Credits: 6
Learning Outcome:This module explores the critical role of enzymes in drug discovery and development, providing students with a comprehensive understanding of how enzymes function as both targets and tools in pharmaceutical research. The course will cover fundamental concepts of enzymology and their practical applications in drug design, screening, and optimization.
Contents:
  • Enzyme structure, function, and kinetics
  • Enzymes as drug targets: identification and validation
  • High-throughput screening methods for enzyme inhibitors
  • Structure-based drug design targeting enzymes
  • Pharmacokinetics and drug metabolism: role of metabolizing enzymes
  • Enzyme engineering for drug discovery and development
  • Prodrug strategies and enzyme-activated therapeutics
  • Drug-drug interactions mediated by enzymes
  • Emerging technologies in enzyme-based drug discovery
Recommended Prerequisites:None
Mandatory Prerequisites:None
Forms of Teaching and Proportion:
  • Lecture / 2 Hours per Week per Semester
  • Seminar / 2 Hours per Week per Semester
  • Self organised studies / 120 Hours
Teaching Materials and Literature:
  • "Enzymes and Their Inhibitors: Drug Development" edited by H. John Smith and Claire Simons
  • "Opportunities for Accelerating Drug Discovery and Development by Applying Engineered Drug-Metabolizing Enzymes" by Guo-Qiang Chen, published in Drug Metabolism and Disposition
Module Examination:Prerequisite + Final Module Examination (MAP)
Assessment Mode for Module Examination:Prerequsite:
  • Successful completion of the seminar including a 30 min presentation and 15 min discussion
Final Module Examination:
  • Final written examination (120 min)
Evaluation of Module Examination:Performance Verification – graded
Limited Number of Participants:None
Part of the Study Programme:
  • Bachelor (research-oriented) / Life Science and International Health / PO 2025
Remarks:None
Module Components:
  • Lecture
  • Seminar
Components to be offered in the Current Semester:
  • no assignment