Publikationen

2021

Kiebist, J., Schmidtke, K.-U., Schramm, M., König, R., Quint, S., Kohlmann, J., Zuhse, R., Ullrich, R., Hofrichter, M., Scheibner, K. (2021): Biocatalytic syntheses of antiplatelet metabolites of the thienopyridines clopidogrel and prasugrel using fungal peroxygenases. Journal of Fungi, Vol. 7 (9), 752 (doi: 10.3390/jof7090752).

Bello, S., Pérez, N., Kiebist, J., Scheibner, K., Ruiz, M.I.S., Serrano, A., Martínez, A.T., Feijoo, G. & Moreira, M.T. (2021): Early-stage sustainability assessment of enzyme production in the framework of lignocellulosic biorefinery. Journal of Cleaner Production, Vol. 285, 125461 (doi: 10.1016/j.jclepro.2020.125461).

Gomez de Santos, P., Dat Hoang, M, Kiebist, J., Kellner, H., Ullrich, R., Scheibner, K., Hofrichter, M., Liers, C. & Alcalde, M. (2021): The functional expression in yeast of two unusual acidic peroxygenases from Candolleomyces aberdarensis by adopting evolved secretion mutations. Applied & Environmental Microbiology, AEM-00878. (doi: 10.1128/AEM.00878-21).

González-Benjumea, A., Marques, G., Herold-Majumdar, O.M., Kiebist, J., Scheibner, K., Del Rio, J.C., Martínez, A.T., Gutiérrez, A. (2021): High epoxidation yields of vegetable oil hydrolyzates and methyl esters by selected fungal peroxygenases. Frontiers in Bioengineering and Biotechnology, Vol. 8, 1470 (doi: 10.3389/fbioe.2020.605854).

2020

Ingenbosch, K.N., Quint, S., Dyllick-Brenzinger, M., Wunschik, D.S., Kiebist, J., Süss, P., Liebelt, U., Zuhse, R., Menyes, U., Scheibner, K., Mayer, C., Opwis, K., Gutmann, J.S., Hoffmann-Jacobsen K. (2020): Singlet oxygen generation by peroxidases and peroxygenases for chemo-enzymatic synthesis. ChemBioChem, Vol. 21, 1-11 (doi: 10.1002/cbic.202000326)

Kiebist, J., Steinbrecht, S., König, R., Thiessen, M., Schmidtke, K.-U., Kammerer, S., Küpper, J.-H. & Scheibner, K. (2020): Synthesis of cyclophosphamide metabolites by a peroxygenase from Marasmius rotula for toxicological studies on human cancer cells. AMB Express, Vol. 10 (1), 1-13 (doi: 10.1186/s13568-020-01064-w).

Babot, E., Aranda, C., del Río, J.C., Ullrich, R., Kiebist, J., Scheibner, K., Hofrichter, M., Martínez, A.T., Gutierrez, A. (2020): Selective oxygenation of ionones and damascones by fungal peroxygenases. Journal of Agriculture and Food Chemistry, Vol. 68 (19), 5375-5383 (doi: 10.1021/acs.jafc.0c01019).

Scheibner, K., Ullrich, R., Kiebist, J., Kellner, H. & Hofrichter, M. (2020). Unspezifische Peroxygenasen - Oxyfunktionalisierung außerhalb der Pilzhyphe. BIOspektrum, Vol. 26: 103–106 ( doi: 10.1007/s12268-020-1338-x).

2019

Aranda, C., Municoy, M., Gullar, V., Kiebist, J., Scheibner, K., Ullrich, R., del Rio, J.C., Hofrichter, M., Martínez, A.T., Gutierrez, A. (2019). Selective Synthesis of 4-Hydroxyisophorone and 4-Ketoisophorone by Fungal Peroxygenases. Catalysis Science & Technology, Vol. 9: 1398-1405 (doi: 10.1039/C8CY02114G).

Steinbrecht, S., König, R., Schmidtke, K.-U., Herzog, N., Scheibner, K., Krüger-Genge, A., Jung, F., Kammerer, S., Küpper, J.-H. (2019). Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4. Toxicology, Vol. 412: 37-47 (doi: 10.1016/j.tox.2018.11.008).

2018

Aranda, C., Olmedo, A., Kiebist, J., Scheibner, K., del Río, J.C., Martínez, A.T. & Gutiérrez, M. (2018). Selective Epoxidation of Fatty Acids Methyl Esters by Fungal Peroxygenases. ChemCatChem, Vol. 10: 3964-3968 (doi: 10.1002/cctc.201800849).

Ullrich, R., Poraj-Kobielska, M., Scholze, S., Halbout, C., Sandvoss, M., Pecyna, M.J., Scheibner, K. & Hofrichter, M. (2018). Side chain removal from corticosteroids by unspecific peroxygenase. Journal of Inorganic Biochemistry, Vol. 183: 84-93 (doi: 10.1016/j.jinorgbio.2018.03.011).

Aranda, C., Ullrich, R., Kiebist, J., Scheibner, K., del Rio, J.C., Hofrichter, M., Martinez, A. T. & Gutiérrez A. (2018). Selective synthesis of the resveratrol analogue 4,4'-dihydroxy-trans-stilbene and stilbenoids modification by fungal peroxygenases. Catalysis Science & Technology, Vol. 8: 2394-2401 (doi: 10.1039/C8CY00272J).

2017

Martínez, T. A., Ruiz-Duenas, F. J., Camarero, S., Serrano, A., Linde, D., Tovborg, M., Herold-Majumdar, O. M., Hofrichter, M., Liers, Christiane, Ullrich, R., Scheibner, K., Sannia, G., Piscitelli, A., Pezzela, C., Sener, M. E., Kilic, S., van Berkel, W. J. H., Gullar, V., Lucas, M. F., Zuhse, R., Ludwig, R., Hollmann, F., Fernández-Fueyo, E., Record, E., Faulds, C. B., Tortajada, M., Winckelmann, Ib, Rasmussen, J.-A., Gelo-Pujic, M., Gutiérrez, A., del Río, J. C., Rencoret, J.  & Alcalde, M. (2017). Oxidoreductases on their way to industrial biotransformations. Biotechnology Advances (doi: 10.1016/j.biotechadv.2017.06.003).

Kiebist, J., Schmidtke, K.-U., Zimmermann, J., Kellner, H., Jemlich, N., Ullrich, R., Zänder, D., Hofrichter, M. & Scheibner, K. (2017). A peroxygenase from Chaetomium globosum catalyzes the selective oxygenation of testosterone. ChemBioChem, Vol. 18: 563-569 (doi: 10.1002/cbic.201600677).

Karich, A., Ullrich, R., Scheibner, K.,  & Hofrichter, M. (2017). Fungal unspecific peroxygenases oxidize the majority of organic EPA priority pollutants. Frontiers in Microbiology, Vol. 8: article 1463 (doi: 10.3389/fmicb.2017.01463).

Olmedo, A., del Río, J. C., Kiebist, J., Scheibner, K., Martínez, A. T. & Gutiérrez, A. (2017). Fatty Acid Chain Shortening by a Fungal Peroxygenase. Chemistry A European Journal (Accepted Manuscript, doi: 10.1002/chem.201704773).

2016

Karich, A., Scheibner, K., Ullrich, R. & Hofrichter, M. (2016). Exploring the catalase activity of unspecific peroxygenases and the mechanism of peroxide-dependent heme destruction. The Journal of Molecular Catalysis B: Enzymatic, Vol. 134: 238-246 (doi: 10.1016/j.molcatb.2016.10.014).

Olmedo, A., Aranda, C., del Rio, J. C., Kiebist, J., Scheibner, K., Martínez, A. T. & Gutiérrez, A. (2016). From Alkanes to Carboxylic Acids: Terminal Oxygenation by a Fungal Peroxygenase. Angewandte Chemie International Edition, Vol. 55(40): 12248-51 (doi: 10.1002/anie.201605430).

Herzog, N., Hansen, M., Miethbauer, S., Schmidtke, K.-U., Anderer, U., Lupp, A., Sperling, S., Seehofer, D., Damm, G., Scheibner, K. & Küpper, J.-H. (2016). Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures. Cell Biology International, Vol. 40(3): 341-353 (doi: 10.1002/cbin.10574).

2015

Kiebist, J., Holla, W., Heidrich J., Poraj-Kobielska, M., Sandvoss, M., Simonis, R., Gröbe, G., Atzrodt, J., Hofrichter, M. & Scheibner, K. (2015). One-pot synthesis of Human Metabolites of SAR548304 by fungal peroxygenases. Bioorganic & Medicinal Chemistry, Vol. 23(15): 4324-32 (doi:10.1016/j.bmc.2015.06.035)

Babot, E.D., Del Rio, J.C., Canellas, M., Sancho, F., Lucas, F., Guallar, V., Kaum, L., Lund, H., Grobe, G., Scheibner, K., Ullrich, R., Hofrichter, M., Martinez, A.T. & Gutierrez, A. (2015). Steroid hydroxylation by basidiomycete peroxygenases: A combined experimental and computational study. Applied and Environmental Microbiology, Vol. 81(12): 4130-42 (doi:10.1128/AEM.00660-15)

Poraj-Kobielska, M., Peter, S., Leonhardt, S., Ullrich, R., Scheibner, K. & Hofrichter, M. (2015). Immobilization of unspecific peroxygenases (EC 1.11.2.1) in PVA/PEG gel and hollow fiber modules. Biochemical Engineering Journal, Vol. 98: 144-150 (doi:10.1016/j.bej.2015.02.037)

2014

Martínez, A. T., Ruiz-Dueñas, F. J., Gutiérrez, A., del Río, J. C., Alcalde, M., Liers, C., Ullrich, R., Hofrichter, M., Scheibner, K., Kalum, L., Vind, J. & Lund, H. (2014). Search, engineering and applications of new oxidative biocatalysts. Review. Biofuels, Bioproducts & Biorefining, Vol. 8: 819-835. (doi:10.1002/bbb.1498)

2013

Piontek, K., Strittmatter, E., Ullrich, R., Gröbe, G. Pecyna, M. J., Kluge, M., Scheibner, K., Hofrichter, M. & Plattner D. A. (2013). Structural basis of substrate conversion in a new aromatic peroxygenase: P450 functionality with benefits. The Journal of Biological Chemistry, Vol. 288: 34767-34776. (doi:10.1074/jbc.M113.514521)

Kluge, M., Ullrich, R., Scheibner, K. & Hofrichter, M. (2013): Formation of naphthalene hydrates in the enzymatic conversion of 1,2-dihydronaphthalene by two fungal peroxygenases and subsequent naphthalene formation. Journal of Molecular Catalysis B: Enzymatic, Special Issue: ChemBioTec, Vol. 103: 56-60. (DOI:10.1016/j.molcatb.2013.08.017)

Peter, S., Karich, A., Ullrich, R., Gröbe, G., Scheibner, K. & Hofrichter, M. (2013): Enzymatic one-pot conversion of cyclohexane into cyclohexanone:Comparison of four fungal peroxygenases. Journal of Molecular Catalysis B: Enzymatic, Special Issue: ChemBioTec, Vol. 103: 47-51. (doi:10.1016/j.molcatb.2013.09.016)

Poraj-Kobielska, M., Atzrodt, J., Holla, W., Sandvoss, M., Gröbe, G., Scheibner, K. & Hofrichter, M. (2013): Preparation of labeled human drug metabolites and drug-drug interaction-probes with fungal peroxygenases. Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 56: 513-519 (doi:10.1002/jlcr.3103).

Friedrich, S., Gröbe, G., Kluge, M., Brinkmann, T., Hofrichter, M. & Scheibner, K. (2013). Optimization of a biocatalytic process to gain (R)-1-phenylethanol by applying the software tool Sabento for ecological assessment during the early stages of development. Journal of Molecular Catalysis B: Enzymatic, Vol. 103: 36-40. (doi:10.1016/j.molcatb.2013.10.002)

2012

Yarman, A., Gröbe, G., Neumann, B., Kinne, M., Gajovic-Eichelmann, N., Wollenberger, U., Hofrichter, M., Ullrich, R., Scheibner, K. & Scheller, F. W. (2012): The aromatic peroxygenase from Marasmius rutola - a new enzyme for biosensor applications. Analytical and Bioanalytical Chemistry, Vol. 402: 405-412. (doi:10.1007/s00216-011-5497-y)

Kluge, M., Ullrich, R., Scheibner, K. & Hofrichter, M. (2012): Stereoselective benzylic hydroxylation of alkylbenzenes and epoxidation of styrene derivatives catalyzed by the peroxygenase of Agrocybe aegerita. Green Chemistry, Vol. 14: 440-446. (doi:10.1039/C1GC16173C)

Poraj-Kobielska, M., Kinne, M., Ullrich, R., Scheibner, K. & Hofrichter M. (2012): A spectrophotometric assay for the detection of fungal peroxygenases. Analytical Biochemistry, Vol. 421: 327-329. (doi:10.1016/j.ab.2011.10.009)

2011

Gröbe, G., Ullrich, R., Pecyna, M. J., Kapturska, D., Friedrich, S., Hofrichter M. & Scheibner, K. (2011): High-yield production of aromatic peroxygenase by the agaric fungus Marasmius rotula. AMB Express, Vol. 1: 31. (doi:10.1186/2191-0855-1-31)

Yarman, A., Peng, L., Wu, Y., Bandodkar, A., Gajovic-Eichelmann, N., Wollenberger, U., Hofrichter, M. Ullrich, R., Scheibner, K. & Scheller, F.W. (2011): Can peroxygenase and microperoxidase substitute cytochrome P450 in biosensors? Bioanalytical Reviews, Vol. 3: 67-94. (doi:10.1007/s12566-011-0023-4)

Poraj-Kobielska, M., Kinne, M., Ullrich, R., Scheibner, K., Kayser, G., Hammel, K.E. & Hofrichter M. (2011): Preparation of human drug metabolites using fungal peroxygenases. Biochemical Pharmacology, Vol. 82: 789-796. (doi:10.1016/j.bcp.2011.06.020)

Kinne, M., Poraj-Kobielska, M., Ullrich, R., Nousiainen, P., Sipilä, J.,Scheibner, K., Hammel, K.E. & Hofrichter, M. (2011): Oxidative cleavage of non-phenolic β -O-4 lignin model dimers by an extracellular aromatic peroxygenase. Holzforschung, Vol. 65: 673-679.

2010

Peng, L., Wollenberger, U., Kinne, M., Hofrichter, M., Ullrich, R., Scheibner, K., Fischer, A. & Scheller, F. W. (2010): Peroxygenase based sensor for aromatic compounds. Biosensors and Bioelectronics, Vol. 26: 1432-1436.

Peng, L., Wollenberger, U., Hofrichter, M., Ullrich, R., Scheibner, K. & Scheller, F. W. (2010): Bioelectrocatalytic properties of  Agrocybe aegerita peroxygenase. Electrochimica Acta, Electrochimica Acta, Vol. 55: 7809-7813.

2009

Pecyna, M. J., Ullrich, R. Bittner, B., Clemens, A., Scheibner, K., Schubert R. & Hofrichter, M. (2009): Molecular characterization of aromatic peroxygenase from Agrocybe aegerita. Applied Microbiology and Biotechnology, Vol. 84:885-897.

Kinne, M. Poraj-Kobielska, M., Aranda, E., Ullrich, R., Hammel, K. E., Scheibner, K., & Hofrichter, M. (2009): Regioselective preparation of 5-Hydroxypropranolol and 4'-Hydroxydiclofenac with a fungal peroxygenase. Bioorganic & Medicinal Chemistry Letters, Vol. 19: 3085-3087.

Kluge, M. G., Ullrich, R., Dolge, Ch., Scheibner, K. & Hofrichter, M. (2009): Hydroxylation of naphthalene by aromatic peroxygenase from Agrocybe aegerita proceeds via oxygen transfer from H2O2 and intermediary epoxidation. Applied Microbiology and Biotechnology, 81: 1071-1076.

Publikationen bis 2008

Kinne, M., Ullrich, R., Hammel, K. E., Scheibner, K. & Hofrichter, M. (2008): Regioselective preparation of (R)-2-(4-Hydroxyphenoxy)propionic acid with a fungal peroxygenase. Tetrahedron Letters, Vol. 49: 5950-5953.

Kluge, M. G., Ullrich, R., Scheibner, K. & Hofrichter, M. (2007): Spectrophotometric assay for detection of aromatic hydroxylation catalyzed by fungal haloperoxidase-peroxygenase. Applied Microbiology and Biotechnology, Vol. 75: 1473-1478.

Ullrich, R., Nüske, J., Scheibner, K. & Hofrichter, M. (2004): A novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes. Applied Environmental Microbiology, Vol. 70:4575-4581.

Haas, R., Tsivunchyk, O., Steinbach, K., v.Löw, E., Scheibner, K. & Hofrichter, M. (2003): Conversion of adamsite (phenarsazine chloride) by fungal manganese peroxidase. Applied Microbiology and Biotechnology, Vol. 63:564-566.

Haas, R., Scheibner, K. & Hofrichter, M. (2003): Enzymatische Umsetzung von Arsenkampfstoffen durch das Pilzenzym Mangan-Peroxidase. Zeitschrift für Umweltchemie und Ökotoxikologie UWSF, Vol. 15(4):224-226.

Nüske, J., Dornberger, U., Ullrich, R., Scheibner, K. & Hofrichter, M. (2002): Large scale production of manganese peroxidase using white-rot fungi. Enzyme and Microbial Technology, Vol. 30:556-561.

Heine, E., Schuh, E., Daaloul, N., Höcker, H., Breier, R., Schmidt, M., Apitz, A., Brünner, A., van Pée, K.-H. & Scheibner, K. (2001): Oxidative Enzyme in der Textilindustrie, Biokatalyse, Sonderausgabe der DBU, Hrsg. S. Heiden, R. Erb, Spektrum Akad. Verlag, BIOSpektrum, 49-53.

Fritsche, W., Scheibner, K., Herre, A. & Hofrichter, M. (2000): Fungal degradation of explosives: TNT and related nitroaromatic compounds. In: Spain, J. , Hughes, J.B., Knackmuss, H.-J, (eds.) Biodegradation of nitroorganic compounds and explosives. Lewis Publishers, Boca Raton, S. 213-237.

Hofrichter, M., Vares, T., Kalsi M., Scheibner, K. & Hatakka, A. (1999): Production of ligninolytic enzymes and organic acids, and mineralization of 14C-labeled lignin during solid-state fermentation of wheat straw with white-rot fungus Nematoloma frowardii. Applied and Environmental Microbiology, Vol. 65: 1864-1870.

VanAken, B., Hofrichter, M., Scheibner, K., Hatakka, A., Naveau, H. & Agathos, S.N. (1999) : Transformation and mineralization of 2,4,6-trinitrotoluene (TNT) by manganese peroxidase from the white-rot basidiomycete Phlebia radiata. Biodegradation, Vol. 10: 83-91.

Hofrichter, M., Scheibner, K., Bublitz, F., Schneegaß, I., Martens, R. & Fritsche, W. (1999): Depolymerization of straw lignin by manganese peroxidase from Nematoloma frowardii is accompanied by release of carbon dioxide. Holzforschung Vol. 52: 161-166.

Hofrichter, M., Vares, T., Scheibner, K., Galkin, S., Sipilä, J. & Hatakka, A. (1999): Mineralization and solubilization of synthetic lignin by manganese peroxidases from Nematoloma frowardii and Phlebia radiata. Journal of Biotechnology, Vol. 67: 217-228.

Hofrichter, M., Scheibner, K., Haas, R., Nüske, J. & Fritsche, W. (1999): Die Mangan-Peroxidase ligninolytischer Pilze: Ein innovatives biokatalytisches System zur Eliminierung von Umwelt-Schadstoffen. In: Heiden, S., Erb, R., Warrelmann, J., Dierstein, R. (Eds.) Biotechnologie im Umweltschutz. S. 108-116. Erich Schmidt Verlag, Berlin.

Hofrichter, M., Scheibner, K., Schneegaß, I., Ziegenhagen, D. & Fritsche, W. (1998): Mineralization of synthetic humic substances by manganese peroxidase from the white-rot fungus Nematoloma frowardii. Applied Microbiology and Biotechnology, Vol. 49(5): 584-588.

Scheibner, K. & Hofrichter, M. (1998): Conversion of aminonitrotoluenes by fungal manganese peroxidases. Journal of Basic Microbiology, Vol. 38(1): 51-59.

Hofrichter, M., Scheibner, K., Schneegaß, I. & Fritsche, W. (1998): Enzymatic combustion of aromatic and aliphatic compounds by manganese peroxidase from Nematoloma frowardii. Applied and Environmental Microbiology, Vol. 64: 399-404.

Schneegaß, I., Hofrichter, M., Scheibner, K. & Fritsche, W. (1997): Purification of the main manganese peroxidase isoenzyme MnP2 from the white-rot fungus Nematoloma frowardii b19. Applied Microbiology and Biotechnology, Vol. 48: 602-605.

Scheibner, K., Herre, A., Michels, J. & Fritsche, W. (1997): Screening for fungi intensively mineralizing 2,4,6-trinitrotoluene. Applied Microbiology and Biotechnology, Vol. 47: 452-458.

Scheibner, K., Hofrichter, M. & Fritsche, W. (1997): Mineralization of 2-amino-4,6-dinitrotoluene by manganese peroxidase of the white-rot fungus Nematoloma frowardii. Biotechnology Letters, Vol 19(9): 835-839.

Scheibner, K., Herre, A., Michels, J. & Fritsche, W. (1997): Bioremediation of 2,4,6-trinitrotoluene (TNT) contaminated soil by a litter decaying fungus. In: In Situ and On-Site Bioremediation, Battelle Press. Vol. 2: 493-498.

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