DFG project "GP2 as a switch for host and individual specificity of intestinal infections"

The project will be funded by the DFG over the period 2013-2018. Currently, three doctoral candidates are working on this project. The zymogen granulamembrane glycoprotein 2 (GP2) is expressed by the follicle-associated epithelium of the gut, influenced by a binding to the bacterial adhesin FimH intestinal infections, also seems to play a major role in Crohn's disease and is the immunomodulator of both innate as well as acquired immunity. Binding to GP2 is specific for individual bacterial species or pathotypes but also for the host animal species. Within the DFG project, the following hypothesis is elucidated: Bacterial intestinal infections are often host-specific and individual. GP2 and its interaction with bacteria on the one hand and its influence on intestinal epithelial cells on cells of the intestinal immune system on the other hand are the basis of this host specificity and individuality.

Project leader: Prof. Dr. Peter Schierack