DFG project "GP2 as a switch for host and individual specificity of intestinal infections"

The project is funded by the DFG over the period 2016-2019.

The zymogen granule membrane glycoprotein 2 (GP2) is expressed by the follicle-associated epithelium of the intestine, influences intestinal infections via binding to the bacterial adhesin FimH, also appears to play a major role in Crohn's disease and is an immunomodulator of both innate and acquired immunity. Binding to GP2 is specific for individual bacterial species or pathotypes but equally for host species. Within the DFG project the following hypothesis will be elucidated: Bacterial intestinal infections are often host-specific and individual. GP2 and its interaction with bacteria on the one hand and its influence via intestinal epithelial cells on cells of the intestinal immune system on the other hand are the basis of this host specificity and individuality. 

Project Management: Prof. Dr. Peter Schierack